Recently,people are confused with two opposite variations of elastic modulus with decreasing size of nano scale sample:elastic modulus either decreases or increases with decreasing sample size.In this paper,based on intermolecular potentials and a one dimensional model,we provide a unified understanding of the two opposite size effects.Firstly,we analyzed the microstructural variation near the surface of an fcc nanofilm based on the Lennard-Jones potential.It is found that the atomic lattice near the surface becomes looser in comparison with the bulk,indicating that atoms in the bulk are located at the balance of repulsive forces,and the elastic moduli decrease with the decreasing thickness of the film accordingly.In addition,the decrease in moduli should be attributed to both the looser surface layer and smaller coordination number of surface atoms.Furthermore,it is found that both looser and tighter lattice near the surface can appear for a general pair potential and the governing mechanism should be attributed to the surplus of the nearest force to all other long range interactions in the pair potential.Surprisingly,the surplus can be simply expressed by a sum of the long range interactions and the sum being positive or negative determines the looser or tighter lattice near surface respectively.To justify this concept,we examined ZnO in terms of Buckingham potential with long range Coulomb interactions.It is found that compared to its bulk lattice,the ZnO lattice near the surface becomes tighter,indicating the atoms in the bulk are located at the balance of attractive forces,owing to the long range Coulomb interaction.Correspondingly,the elastic modulus of one-dimensional ZnO chain increases with decreasing size.Finally,a kind of many-body potential for Cu was examined.In this case,the surface layer becomes tighter than the bulk and the modulus increases with deceasing size,owing to the long range repulsive pair interaction,as well as the cohesive many-body interaction caused by the electron redistribution. Recently, people are confused with two opposite variations of elastic modulus with decreasing size of nano scale sample: elastic modulus either decreases or increases with decreasing sample size. In this paper, based on intermolecular potentials and a one dimensional model, we provide a unified understanding of the two opposite size effects. Firstly, we analyzed the microstructural variation near the surface of an fcc nanofilm based on the Lennard-Jones potential. It is found that the atomic lattice near the surface becomes looser in comparison with the bulk, indicating that atoms in the bulk are located at the balance of repulsive forces, and the elastic moduli decrease with the decreasing thickness of the film accordingly. In addition, the decrease in moduli should be attributed to both the looser surface layer and the smaller coordination number of surface atoms. It is found that both looser and tighter lattice near the surface can appear for a general pair potential and the governing me chanism should be attributed to the surplus of the nearest force to all other long range interactions in the pair potential. Surprisingly, the surplus can be simply expressed by a sum of the long range interactions and the sum being positive or negative determines the looser or tighter lattice near surface respectively. To justify this concept, we examined ZnO in terms of Buckingham potential with long range Coulomb interactions. It is found that compared to its bulk lattice, the ZnO lattice near the surface becomes tighter, indicating the atoms in the bulk are located at the balance of attractive forces, owing to the long range Coulomb interaction. Correspondingly, the elastic modulus of one-dimensional ZnO chain increases with decreasing size. Finally, a kind of many-body potential for Cu was examined. In this case, the surface layer becomes tighter than the bulk and the modulus increases with deceasing size, owing to the long range repulsive pair interaction, as well as the cohesive many-body interaction caused by the electron redistribution.