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５１例肾移植术后患者中随机分组，考查３种新头孢菌素分别与环孢素合并使用时对肾功能及环孢素全血药物浓度的影响。在合并用头孢菌素前、合并用药７ｄ后、停药后７ｄ测定患者的血清肌酐、尿素氮和环孢素全血药物浓度。结果表明，头孢呋辛、头孢曲松在与环孢素合并用药之后，对患者的肾功能无不良影响，且不改变环孢素血药浓度。合并用头孢他啶，虽然没有改变环孢素血药浓度，但有一定的肾毒性，血清肌酐、尿素氮水平较合并用药前增加了２．６％、２７．１％，较停药后增加了６．６％、２９．９％。
51 patients with renal transplantation were randomly divided into three groups to examine the effects of three new cephalosporins combined with cyclosporine on renal function and ciclosporin whole blood drug concentration. Serum creatinine, blood urea nitrogen and cyclosporin blood concentrations were measured at 7 days after the combination of cephalosporins and 7 days after drug combination. The results showed that cefuroxime, ceftriaxone in combination with cyclosporine, the patient’s renal function without adverse effects, and does not change the cyclosporine plasma concentration. The combination of ceftazidime did not change the plasma concentration of ciclosporin, but it had certain nephrotoxicity. Serum creatinine and blood urea nitrogen levels increased by 2.6% and 27.1% respectively compared with those before the combination treatment, increasing by 6% .6%, 29.9%.