在正常情况下,乙型肝炎病毒(HBV)并不能通过“胎盘屏障”,携带HBV、具有高度传染性的母亲,在分娩过程中可由血液或阴道分泌物等,将乙型肝炎传播给新生儿。其后果,能发展成无症状的HBV携带者,严重的可发生暴发性肝炎,造成新生儿死亡或转化为慢性活动性肝炎。关于切断母婴传播这一重要研究课题,已经证实乙肝免疫球蛋白(HBIG)是一种有效的制剂。近年来由于乙肝疫苗的问世,提供了持久的、积极的预防手段,疫苗自动免疫与HBIG的直接被动免疫结合,可增强婴儿的免疫能力,弥补了单纯HBIG预防法停止注射HBIG后不能有效阻止病毒感染的不足,现已被 Under normal circumstances, hepatitis B virus (HBV) can not pass the “placental barrier”, carrying HBV, highly infectious mothers in the process of delivery can be by blood or vaginal discharge, hepatitis B will be transmitted to newborns . Its consequences, can develop asymptomatic HBV carriers, severe fulminant hepatitis can occur, resulting in neonatal death or conversion to chronic active hepatitis. On the important issue of cutting off mother-to-child transmission, hepatitis B immunoglobulin (HBIG) has been shown to be an effective preparation. In recent years, due to the advent of hepatitis B vaccine, providing a long-lasting, active means of prevention, automatic vaccine immunization combined with direct passive immunization of HBIG can enhance the immune capacity of infants, to make up for the simple HBIG prophylaxis can not effectively stop the virus after stopping HBIG injection Insufficient infection has now been