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为了解甘肃省 1996～ 2 0 0 0年疫苗相关麻痹型脊髓灰质炎 (脊灰 )病例 (VAPP)的发生情况 ,利用急性弛缓性麻痹病例监测系统有关资料对VAPP进行分析。结果显示 :1996～ 2 0 0 0年全省共接种口服脊灰疫苗 2 6 2 9万人份 ,发生VAPP 7例 ,发生率为 0 2 7/ 10 0万 ,其中首次服苗者发生 4例 ,发生率为 1 6 2 / 10 0万 ,接触者发生 3例 ,发生率为 0 11/ 10 0万 ;病例呈高度散发 ,年龄均 <3岁 ,男女之比为 6∶1,临床表现典型 ,所有病例都残留麻痹 ;病毒分离以Ⅱ型疫苗相关株为多。实现无脊灰后VAPP的影响不容忽视。
To understand the incidence of vaccine-associated paralytic poliomyelitis (VAPP) in Gansu province from 1996 to 2000, VAPP was analyzed using data from the surveillance system for acute flaccid paralysis cases. The results showed that from 1996 to 2000, a total of 26 920 population of oral polio vaccine were inoculated in the province, with 7 cases of VAPP occurring at a rate of 0 27/10 million, of which 4 cases occurred in the first dose of vaccine , The incidence was 16.2 / 10 million, contact occurred in 3 cases, the incidence was 0 11/10 million; the cases were highly distributed, all <3 years old, male to female ratio of 6: 1, the typical clinical manifestations , All cases were residual paralysis; virus isolated to type II vaccine-related strains. The impact of post-polio-free VAPP can not be ignored.