论文部分内容阅读
目的 探讨幽门螺杆菌(Hp)感染与冠心病经皮冠状动脉介入治疗(PCI)后抗血小板治疗诱发上消化道出血的关系.方法 行PCI术冠心病患者520例 ,围术期均给予氯吡格雷和阿司匹林抗血小板治疗.H p检测结果 :410例 H p感染阳性(A组) ,110例 H p阴性(B组).A组患者随机均分为两组 :A1组采用规范三联用药方案实施 Hp根除治疗 ,A2组未予抗Hp治疗.治疗后随访1年 ,观察上消化道出血发生情况.结果 A组上消化道出血发生率为6.83% ,B组未出现上消化道出血病例.A1组上消化道出血发生率为1.46% ,低于A2组的12.20% (P<0 .05).结论 Hp感染增加冠心病患者PCI术后抗血小板治疗发生上消化道出血的风险 ,抗 Hp治疗能有效降低这种风险.“,”Objective To investigate the relationship of Helicobacter pylori(Hp) infection and upper gastrointestinal tract hemorrhage induced by anti-platelet therapy in the patients underwent percutaneous coronary intervention(PCI) .Methods A total of 520 patients underwent PCI ,who were assigned into two groups of A(with Hp positive ,410 cases) and B(with Hp negative ,110 cases) .All patients were given anti-platelt therapy with clopidogrel and aspirin for PCI .The patients in group A were randomly divided into subgroups of A1 (treated with conventional triple regimen for anti-Hp therapy ,205 cases) and A2(without anti-Hp therapy ,205 cases) .The patients were followed up for one year and the incidence of upper gastrointestinal tract hemorrhage was observed .Results The incidence rate of upper gastrointestinal tract hemorrhage was 6.83% in group A ,which was 0% in group B .The incidence rate of upper gastrointestinal tract hemorrhage was lower in group A1 than that in group A2 (1.46% vs .12.20% )( P<0 .05 ) .Conclusion Hp infection increases the risk for upper gastrointestinal tract hemorrhage in the patients with coronary heart disease underwent PCI , which can be reduced by anti-Hp therapy .