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穿心莲内酯是穿心莲Andrographispaniculata中主要次生代谢物之一。曾报道它对几种实验性肝损伤有保护作用,雄性大鼠口服穿心莲干叶粉末,显示阻止精子生成的作用。作者研究了该化合物对雄性大鼠生殖毒性和抗生育能力。
Andrographolide is one of the major secondary metabolites in Andrographispaniculata. It has been reported that it has a protective effect on several experimental liver injuries. Oral dry powder of Andrographis paniculata in male rats showed the effect of preventing sperm production. The authors studied the reproductive toxicity and anti-fertility of this compound in male rats.