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目的了解阜宁县60μg/1.0 m L重组乙肝疫苗(酿酒酵母)接种后人群免疫水平,完善不同人群的乙肝免疫策略。方法随机抽取16~59岁60名、0~2岁100名,分别采集免疫前及免疫后血样。前者接种1针60μg乙肝疫苗,后者接种3针5μg/(0.5 m L·支)重组乙肝疫苗(酿酒酵母),采用酶联免疫吸附试验法检测抗-HBs。结果60名16~59岁人群中,7名HBs Ag阳性者阴转率71.43%(5/7),抗-HBs阳性率57.14%(4/7);53名健康人群免疫成功率为88.68%(46/53)。0~2岁组免疫成功率88.00%(88/100)。各年龄组、男女阳性率的差异均无统计学意义。结论1针60μg乙肝疫苗与3针5μg/(0.5 m L·支)接种效果相当,且前者接种简便,值得在16~59岁健康人群中推广使用,尤其是低剂量乙肝疫苗低或无应答者的使用,以提高成人接种率和免疫成功率。新婚夫妇和计划怀孕的育龄期妇女应优先使用,以保护自身和胎儿免患乙肝。疫苗接种前宜先筛检后接种,最佳策略是筛检3项(抗-HBs、HBs Ag,抗-HBc)。60μg乙肝疫苗对HBs Ag阳性者可能有一定转阴作用,建议临床方面可作进一步研究。定期做好辖区乙肝疫苗免疫成功率监测等工作。
Objective To understand the immunization level of 60 μg / 1.0 m L recombinant hepatitis B vaccine (Saccharomyces cerevisiae) after inoculation in Funing County and to improve the hepatitis B immunization strategy in different populations. Methods Sixty-six patients aged 60-60 years and 100 children aged 0-2 years were randomly selected. Blood samples were collected before and after immunization. The former was inoculated with a 1-dose 60 μg hepatitis B vaccine, while the latter was inoculated with 3 doses of 5 μg / (0.5 m L · branch) recombinant hepatitis B vaccine (Saccharomyces cerevisiae). Anti-HBs were detected by enzyme-linked immunosorbent assay. Results Among the 60 patients aged 16-59, 7 HBsAg-positive patients had a negative conversion rate of 71.43% (5/7) and anti-HBs positive rate (57.14%, 4/7). The immunization success rate of 53 healthy people was 88.68% (46/53). The success rate of immunization in 0 ~ 2 years group was 88.00% (88/100). There was no significant difference in the positive rates of male and female in all age groups. Conclusions The first dose of 60μg hepatitis B vaccine has the same effect as the third dose of 5μg / (0.5ml), and the former is easy to inoculate and worthy of promotion in healthy population aged 16-59 years, especially low-dose hepatitis B vaccine or non-responders Use to increase adult vaccination rates and immunization success rates. Newly-married couples and women of childbearing age who plan to become pregnant should be given priority to protect themselves and their fetus against hepatitis B. Before vaccination should be screening after vaccination, the best strategy is to screen three (anti-HBs, HBsAg, anti-HBc). 60μg Hepatitis B vaccine may have a negative effect on HBsAg-positive patients, suggesting that further clinical studies may be conducted. Regularly do a good job in the area of hepatitis B vaccine immunization success rate monitoring.