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本文研究了２５例神经母细胞瘤（Ｎｂ），采用胶银染色法测定核仁组成区相关嗜银蛋白（ＡｇＮＯＲ）。发现ＡｇＮＯＲ颗粒每核均数随临床分期级别升高而增加。在分化较低的病理类型中较高，而在分化较好者则较低。ＡｇＮＯＲ颗粒每核均数与有丝分裂核破碎指数（ＭＫＩ）之间存在正相关（ｒ＝０．８６，Ｐ＜０．０１）。另外术前接受化疗组ＡｇＮＯＲ颗粒每核均数较未接受化疗组低。差异显著（Ｐ＞０．０５）。结果表明：ＡｇＮＯＲ胶银染色法在评判Ｎｂ的增生活性及恶性程度方面具有一定的应用意义。
In this study, 25 cases of neuroblastoma (Nb) were studied, and AgNOR was determined by gel silver staining. It was found that the average number of AgNOR particles per nuclear increased with increasing clinical stage. It is higher in less differentiated pathological types and lower in better differentiated individuals. There was a positive correlation between each nuclear average of AgNOR particles and the mitotic nuclear fragmentation index (MKI) (r=0.86, P<0.01). In addition, the average number of AgNOR granules in the preoperative chemotherapy group was lower than that in the non-chemotherapy group. The difference was significant (P>0.05). The results showed that the AgNOR gel silver staining method has certain application significance in judging the proliferation activity and malignancy of Nb.