论文部分内容阅读
目的探讨维生素E对慢性肾衰残肾功能的保护作用及其机理。方法在5/6肾切除大鼠慢性肾衰模型上 ,以假手术大鼠为对照 ,采用生物化学方法 ,对比分析术后30、60、90、120天给予或不给予维生素E治疗的慢性肾衰大鼠残肾功能及其活性氧代谢状况。结果大鼠行5/6肾切除术后 ,残肾氧自由基代谢显著亢进 ,抗氧化能力显著减弱 ,残肾功能进行性恶化。接受维生素E治疗的大鼠 ,残肾氧自由基代谢和抗氧化能力趋于正常 ,残肾功能恶化的速度显著降低。结论维生素E通过其抗氧化作用 ,能显著延缓5/6肾切除所致慢性肾衰大鼠残肾功能进行性恶化的速度
Objective To investigate the protective effect of vitamin E on renal function and its mechanism of chronic renal failure. Methods Chronic renal failure model was established in 5/6 nephrectomized rats. The sham-operated rats were used as control. Biochemical methods were used to compare and analyze the chronic renal failure treated with vitamin E at 30, 60, 90, 120 days after operation Decidual renal function and reactive oxygen metabolism in rats. Results After 5/6 nephrectomy in rats, the remnant kidney oxygen radical metabolism was significantly hyperthyroidism, the antioxidant capacity was significantly weakened, and the residual renal dysfunction progressed. After receiving vitamin E treatment, remnant oxygen free radical metabolism and anti-oxidant capacity tended to be normal, and the rate of residual renal dysfunction was significantly reduced. Conclusion Vitamin E can significantly delay the progressive deterioration of residual renal function in rats with chronic renal failure caused by 5/6 nephrectomy through its antioxidant effect