糖尿病周围神经病变是糖尿病最常见的慢性并发症之一。目前已发现与高血糖相关的多个病理机制。近年胰岛素和C肽的作用得到重视,胰岛素和C肽缺乏能够干扰神经纤维中神经营养因子代谢并引起氧化应激,同时可能与周围和中枢神经系统中出现的细胞凋亡有关。对糖尿病周围神经病变机制进一步的研究将为其预防和治疗提供更好的理论基础。 Diabetic peripheral neuropathy is one of the most common chronic complications of diabetes. Has been found in multiple pathologies associated with hyperglycemia. In recent years, attention has been paid to the role of insulin and C-peptide. Insulin and C-peptide deficiency can interfere with the metabolism of neurotrophic factors in nerve fibers and cause oxidative stress, and at the same time, it may be related to apoptosis in peripheral and central nervous system. Further research on the mechanism of diabetic peripheral neuropathy will provide a better theoretical basis for its prevention and treatment.