【摘 要】
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The development of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is a significant advancement in our ability to obtain cardiomyocytes in vitro f
【机 构】
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Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China“,”Clinic
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The development of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is a significant advancement in our ability to obtain cardiomyocytes in vitro for regenerative therapies and drug discovery.However,hPSC-CMs obtained via existing protocols usually exhibit a markedly immature phenotype,compared with adult cardiomyocytes,thereby limiting their application.Here we report that barbaloin preconditioning dramatically improves the morphology,structurerelated cardiac gene expression,calcium handling,and electrophysiological properties of hPSC-CMs,which means that barbaloin may have the potential to induce the maturation of hPSC-CMs,providing a novel strategy to generate more adult-like cardiomyocytes and promoting the application of hPSC-CMs in regenerative medicine,drug development,and disease modeling.
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