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目的:探讨不同剂量的米非司酮治疗子宫肌瘤患者的临床效果。方法:选取我院2013年4月-2014年5月收治的子宫肌瘤患者共96例作为研究对象,使用随机数字表法将其分为观察组以及对照组各48例。其中观察组患者给予小剂量米非司酮12.5mg治疗,对照组患者给予常规剂量米非司酮25mg治疗,对比两组患者治疗前后子宫肌瘤体积变化情况,同时统计两组患者治疗过程中不良反应发生率,比较两组患者血清卵泡刺激素、黄体生成素、雌二醇以及孕酮等各项激素指标的变化情况。结果:观察组患者治疗后子宫肌瘤体积明显低于对照组,两者对比差异有统计学意义(P<0.05)。观察组患者激素指标下降程度明显高于对照组,对比差异有统计学意义(P<0.05)。两组患者不良反应发生率对比差异有统计学意义(P<0.05)。结论:小剂量米非司酮治疗子宫肌瘤患者疗效更加优秀,患者子宫肌瘤体积显著缩小,不良反应发生率更低。
Objective: To investigate the clinical effect of different doses of mifepristone in patients with uterine fibroids. Methods: A total of 96 patients with uterine fibroids who were treated in our hospital from April 2013 to May 2014 were selected as study subjects, and divided into observation group and control group with 48 cases in each group by random number table. Patients in the observation group were treated with 12.5 mg mifepristone at a low dose and 25 mg mifepristone at a normal dose in the control group. The changes in the volume of uterine fibroids before and after treatment were compared between the two groups. At the same time, The incidence of reaction, the two groups of patients with serum follicle stimulating hormone, luteinizing hormone, estradiol and progesterone and other hormonal changes. Results: The volume of uterine fibroids in the observation group was significantly lower than that in the control group, the difference was statistically significant (P <0.05). The decrease of hormone in observation group was significantly higher than that in control group, the difference was statistically significant (P <0.05). There was significant difference in the incidence of adverse reactions between the two groups (P <0.05). Conclusion: The efficacy of low dose mifepristone in treatment of uterine fibroids is more excellent. The volume of uterine fibroids is significantly reduced and the incidence of adverse reactions is lower.