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Toll样受体4(TLR4)是天然免疫系统识别病原微生物的主要受体,在天然免疫反应中有重要作用。而病毒性心肌炎(VMC)及扩张型心肌病(DCM)的发生和发展均与特异性免疫密切相关,TLR4通过增加病毒复制以及影响细胞因子的产生,加重心肌炎症、引起心肌细胞肥厚和坏死,从而影响VMC和DCM的发生、发展和预后。抑制TLR4基因表达及其信号通路可阻止心肌细胞凋亡,故以此为基础的针对VMC和DCM的治疗有潜在临床应用价值。
Toll-like receptor 4 (TLR4) is the primary receptor for the innate immune system to recognize pathogenic microorganisms and plays an important role in the innate immune response. However, the occurrence and development of viral myocarditis (VMC) and dilated cardiomyopathy (DCM) are closely related to specific immunity. TLR4 increases myocardial inflammation by inducing viral replication and cytokine production, inducing cardiomyocyte hypertrophy and necrosis, Thus affecting the occurrence, development and prognosis of VMC and DCM. Inhibition of TLR4 gene expression and its signaling pathway can prevent myocardial cell apoptosis, so based on this for the treatment of VMC and DCM have potential clinical value.