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目的探讨高尿酸血症(HUA)与良性前列腺增生(BPH)的相关性。方法选择2010年5月在我院体检中心体检的老年男性共666例,测量血压、腹围,现场询问病史和进行国际前列腺症状评分(IPSS),检测空腹血尿酸、TG、TC、LDL-C、HDL-C、空腹血糖、餐后2小时血糖和血清PSA等,超声测量及计算前列腺体积。按血尿酸是否>420μmol/L分为HUA组(n=151)和血尿酸正常组(n=515)。比较两组代谢指标及前列腺相关指标的差异,并采用logistic回归模型分析HUA与各临床指标的相关性。结果 HUA与腹型肥胖[OR=1.575,95%C(I1.059,2.340)]、高TG血症[OR=2.78,95%CI(1.877,4.118)]、代谢综合征(CDS2007)[OR=1.912,95%CI(1.267,2.885)]、BPH[OR=1.464,95%CI(1.465,1.635)]及下尿路症状评级[OR=1.782,95%CI(1.173,1.522)]有明显相关性(P<0.05)。结论 HUA与BPH具有明显相关性,且同时伴发其他心血管危险因素风险高,因此,在诊治其中一种疾病时应重视其他危险因素的筛查及管理。
Objective To investigate the relationship between hyperuricemia (HUA) and benign prostatic hyperplasia (BPH). Methods A total of 666 senile males were examined at our physical examination center in May 2010 to measure blood pressure, abdominal circumference, on-site medical history, IPSS, fasting serum uric acid, TG, TC, LDL-C , HDL-C, fasting blood glucose, 2-hour postprandial blood glucose and serum PSA, ultrasound measurement and calculation of prostate volume. The patients were divided into HUA group (n = 151) and normal blood uric acid group (n = 515) according to whether uric acid> 420μmol / L. The differences of metabolic indexes and prostate-related indexes between the two groups were compared. The correlation between HUA and each clinical index was analyzed by logistic regression model. Results HUA was associated with abdominal obesity [OR = 1.575,95% C (I1.059,2.340)], hypercholesteremia (OR = 2.78,95% CI 1.877,4.118), metabolic syndrome (CDS2007) = 1.912,95% CI 1.267,2.885 BPH OR = 1.464,95% CI 1.465,1.635) and lower urinary tract symptoms [OR = 1.782,95% CI 1.173,1.522] Correlation (P <0.05). Conclusion HUA and BPH have obvious correlation, and at the same time with high risk of other cardiovascular risk factors, therefore, in the diagnosis and treatment of one of the diseases should pay attention to screening and management of other risk factors.