糖皮质激素(Glucocorticoid,GC)具有抑制免疫应答、抗炎、抗休克等作用,因此广泛应用于肾脏疾病、风湿免疫性疾病、器官移植、炎症性肠病等临床疾病。然而,不同患者间GC的治疗效果及不良反应却存在差异,部分患者对GC抵抗或对GC依赖, Glucocorticoid (GC), which has the effects of inhibiting immune response, anti-inflammation and anti-shock, is widely used in clinical diseases such as kidney disease, rheumatic autoimmune disease, organ transplantation and inflammatory bowel disease. However, the treatment effect and adverse reactions of GC in different patients are different, some patients are resistant to GC or GC-dependent,