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肾病综合征(NS)是以大量蛋白尿、低蛋白血症、高脂血症及不同程度水肿为特征的。所以高脂血症是NS的一个重要临床特征。且一直用来作为NS的诊断标准之一。近年来对NS高脂血症的病理生理。脂质紊乱的特征及其对心血管及肾脏病本身的影响引起了众多医学工作者的重视。因此,对NS高脂血症的治疗也就显得更为重要。 1 NS高脂血症的发生率 NS高脂血症的确切发生率尚不清楚,Chopra等报道,在成人NS中为52％。Appel等观察20例成人NS,发现20％血浆总胆固醇升高,55％低密度脂蛋白(LDL)胆固醇升高,30％极低密度脂蛋白(VLDL)胆固醇升高。不少学者证实,高脂血症不是在所有的NS患者中都出现,有些持续重度蛋白尿患者可无明显脂质异常。
Nephrotic syndrome (NS) is characterized by massive proteinuria, hypoproteinemia, hyperlipidemia and varying degrees of edema. Therefore, hyperlipidemia is an important clinical feature of NS. And has been used as one of the NS diagnostic criteria. In recent years, the pathophysiology of hyperlipidemia in NS. The characteristics of lipid disorders and its impact on cardiovascular and renal disease itself has attracted the attention of many medical workers. Therefore, the treatment of NS hyperlipidemia is even more important. 1 The incidence of NS hyperlipidemia The exact incidence of NS hyperlipidemia is unclear, Chopra et al reported that 52% of adult NS. Appel et al observed 20 adult NS patients and found that 20% plasma total cholesterol increased, 55% LDL cholesterol increased, and 30% VLDL cholesterol increased. Many scholars have confirmed that hyperlipidemia is not present in all NS patients, and some patients with persistent severe proteinuria may not have significant lipid abnormalities.