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iv莲心碱(Lien)3mg/kg可一过性地抑制麻醉或毁脊髓大鼠血流动力学诸指标,对麻醉大鼠LVP,+dp/dt_(max)及SAP的抑制较奎尼丁(Qui)3mg/kg为强;Lien 1～30 mg/kg可依量性地产生上述效应,12mg/kg的Lien和Qui分别使LVP,+dp/dt_(max),SAP下降33％,37％,29％和9％,12％,9％,而二者对其它血流动力学参数的抑制程度却相近。Lien 12 mg/kg对血流动力学诸指标的抑制强度与维拉帕米(Ver)1 mg/kg相似。Lien 1～100μmol/L可浓度依赖性地抑制左房收缩力和右房频率。提示其对血流动力学影响的特性与Ver更相似而与Qui有别。
iv Lien (3mg / kg) could inhibit the hemodynamics of anesthetized or destructed spinal cord rats for a long time. The inhibition of LVP, + dp / dt max and SAP in anesthetized rats was significantly lower than that of quinidine Qui 3mg / kg was stronger than the control group. Lien 1 ~ 30mg / kg could produce the above effects in a dose-dependent manner. Lien and Qui at 12mg / kg reduced the levels of LVP, + dp / dtmax and SAP by 33% and 37% , 29% and 9%, 12% and 9%, respectively, while the inhibition of other hemodynamic parameters was similar. Lien 12 mg / kg on hemodynamic indicators of inhibitory strength and verapamil (Ver) 1 mg / kg similar. Lien 1 ~ 100μmol / L concentration-dependent inhibition of left atrial contractility and right atrial frequency. Suggesting that its hemodynamic properties similar to Ver and Qui and Qui different.