目的诱导肺癌干细胞进入分裂期以提高对化疗药物的敏感度。方法未手术晚期肺腺癌患者115例随机分为诱导化疗组(试验组)和常规化疗组(对照组)。两组均予以长春瑞滨+顺铂(NP)方案化疗;试验组化疗期间加用重组人粒细胞集落刺激因子(rhG-CSF)诱导肺癌干细胞分化。化疗2个周期后2周比较两组的疗效。结果试验组近期有效率明显高于对照组(61.8%vs.41.5%)(P<0.05)。结论通过诱导肺癌干细胞向相应的成熟细胞分化使其对化疗敏感,可以提高治疗效果。 Objective To induce lung cancer stem cells into the dividing stage to improve the sensitivity of chemotherapy drugs. Methods 115 patients with advanced lung adenocarcinoma without surgery were randomly divided into induction chemotherapy group (experimental group) and conventional chemotherapy group (control group). Both groups were treated with vinorelbine + cisplatin (NP) chemotherapy. In the experimental group, recombinant human granulocyte colony-stimulating factor (rhG-CSF) was used to induce the differentiation of lung cancer stem cells during chemotherapy. Two weeks after 2 cycles of chemotherapy, the efficacy of the two groups was compared. Results The effective rate of the experimental group was significantly higher than that of the control group (61.8% vs.41.5%) (P <0.05). Conclusion Inducing lung cancer stem cells to differentiate into corresponding mature cells makes them sensitive to chemotherapy, which can improve the therapeutic effect.