肾小球滤过屏障的分子成份 ,如硫酸肝素、nephrin、CD2AP、podocin等 ,具有多种生物活性功能。它们的正常表达及分布对维持滤过膜完整的形态结构和屏障功能有着重要意义。若发生异常将导致大量蛋白尿的产生。这些膜分子成份的发现为进一步研究蛋白尿的发病机制指明了方向 ,为其治疗提供新的途径 The molecular components of the glomerular filtration barrier, such as heparin sulfate, nephrin, CD2AP, podocin, etc., with a variety of biological activity. Their normal expression and distribution of filtration membrane to maintain the integrity of the morphological structure and barrier function is of great significance. If abnormalities will lead to a large number of proteinuria. The discovery of these molecular components of the membrane has pointed out the direction for further studying the pathogenesis of proteinuria and provided a new way for its treatment