Henoch—Schnlein紫癜(HSP)是以广泛血管炎为特征的临床综合征,主要表现为非血小板减少性紫癜,关节炎、胃肠道出血及肾炎,存在循环免疫复合物,临床及组织病理学表现可能是因免疫复合物沉积在小血管壁及肾小球膜所致。HSP病因不明,在临床及实验室检查方面有些与SLE相似之处,但既往未检出过抗核抗体(ANA)。本文报导2例典型HSP病儿血清检出ANA。例1,4岁,女性,平素健康,在下肢及足部肿胀的基础上出现紫癜,行动困难,伴痉挛性腹 Henoch-Schnlein purpura (HSP) is a clinical syndrome characterized by a wide range of vasculitis, mainly manifested as non-thrombocytopenic purpura, arthritis, gastrointestinal bleeding and nephritis with circulating immune complexes, clinical and histopathological manifestations May be due to the deposition of immune complexes in the small blood vessel wall and the glomerular membrane caused. The etiology of HSP is somewhat unknown, with some similarities to SLE in clinical and laboratory tests, but no anti-nuclear antibody (ANA) has ever been detected. This article reports two cases of typical HSP children sera detected ANA. Example 1,4-year-old woman, usually healthy, purpura in the lower extremities and foot swelling, difficulty in movement, with spastic stomach