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一个实体瘤在体内生长,能刺激宿主引起一系列反应。在瘤体局部的机体反应,包括淋巴网状反应(淋巴细胞、巨噬细胞反应)、血管生成反应、纤维反应(纤维母细胞增殖)等等。这些反应大都是机体排斥或阻止肿瘤发展的重要组成部分。然而,血管生成反应恰适得其反。尽管瘤体的这种血管生成,可导致种种血管内肿瘤杀伤因素的抵达,但事与愿违,其结局是这些新血管促进了肿瘤的迅猛生长。本文就血管生成反应作一扼要介绍。
A solid tumor grows in the body and can stimulate the host to cause a series of reactions. The body’s local reaction in the tumor includes lymphatic reticular reaction (lymphocyte, macrophage reaction), angiogenic reaction, fibrogenic reaction (fibroblast proliferation) and so on. These reactions are largely an important part of the body’s rejection or prevention of tumor development. However, the angiogenic response is just the opposite. Although this angiogenesis of tumors can lead to the arrival of various intravascular tumor killing factors, it is counterproductive and the outcome is that these new blood vessels promote the rapid growth of tumors. This article gives an overview of the angiogenic response.