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1927年Fremont-Smith与Forbes建议应用尿素降低颅内压,1954年Javid与Sattlage始用于临床,以后各地陆续开始应用,成为目前降低颅内压及眼内压的最有效药物.Galin氏用于各型青光眼及视网膜剥离手术,Joseph与Frieolmen用于白内障手术时以避免玻璃体之脱出,神经外科应用于降低颅内压消除脑水肿,在脑外伤、脑肿瘤手术,脑造影等方面也有广泛之适应症.最近王氏还报告抢救中毒型痢疾终末期的循环衰竭和呼吸
In 1927, Fremont-Smith and Forbes suggested that urea should be used to reduce intracranial pressure. Javid and Sattlage started to be used clinically in 1954. Afterwards, it gradually became the most effective drug for reducing intracranial pressure and intraocular pressure.Galin’s Various types of glaucoma and retinal detachment surgery, Joseph and Frieolmen for cataract surgery to avoid the prolapse of vitreous, neurosurgery used to reduce intracranial pressure to eliminate cerebral edema, in brain trauma, brain tumor surgery, cerebral angiography also has a wide range of adaptation Wang recently reported on the rescue of end-stage circulatory failure and respiratory poisoning of dysentery