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本文应用粘液组化对366例伴肠化的胃粘膜标本进行检测,并将从中检获的70例异型增生和早期胃癌,作胃癌单抗MG_7检查,结果发现良性病变以完全性小肠化生为主;良恶性病变中,完全性小肠化生及不完全性结肠化生的差别,有极显著差异(P<0.01)。异型增生时MG_7及HID 染色的阳性率随其去分化的级别的增加而增加。但与阳性度则无显著相关性;而在胃癌则MG_7与HID 染色阳性率皆随癌的分化程度降低而逐步减少。
In this paper, mucinomics was used to detect 366 gastric mucosal specimens with intestinal metaplasia, and 70 cases of dysplasia and early gastric cancer seized from them were examined as gastric cancer monoclonal antibody MG_7. The results showed that benign lesions were mainly composed of complete intestinal metaplasia. In benign and malignant lesions, the difference between complete small intestine metaplasia and incomplete colon metaplasia was extremely significant (P<0.01). The positive rate of MG_7 and HID staining on dysplasia increased with increasing grade of dedifferentiation. However, there was no significant correlation with the positive degree. In gastric cancer, the positive rate of MG_7 and HID staining decreased with the degree of differentiation of the cancer.