Aphasia is an acquired language disorder that is a common consequence of stroke. hTe pathogenesis of the disease is not fully understood, and as a result, current treatment options are not satisfactory. Here, we used blood oxygenation level-dependent functional magnetic reso-nance imaging to evaluate the activation of bilateral cortices in patients with Broca’s aphasia 1 to 3 months atfer stroke. Our results showed that language expression was associated with multiple brain regions in which the right hemisphere participated in the generation of lan-guage. hTe activation areas in the letf hemisphere of aphasia patients were signiifcantly smaller compared with those in healthy adults. hTe activation frequency, volumes, and intensity in the regions related to language, such as the letf inferior frontal gyrus (Broca’s area), the letf superior temporal gyrus, and the right inferior frontal gyrus (the mirror region of Broca’s area), were lower in patients compared with healthy adults. In contrast, activation in the right superior temporal gyrus, the bilateral superior parietal lobule, and the letf inferior temporal gyrus was stronger in patients compared with healthy controls. hTese results suggest that the right inferior frontal gyrus plays a role in the recovery of language function in the subacute stage of stroke-related aphasia by increasing the engagement of related brain areas.