论文部分内容阅读
目的探讨环氧合酶-2(COX-2)和生存素(Survivin)在胃癌的发生、发展过程中的作用。方法选择61例胃癌组织和15例正常胃组织,采用免疫组化方法检测两种组织的COX-2和Survivin的表达情况。结果在61例胃癌组织中,有46例COX-2胞浆阳性表达(75.4%),正常胃组织为阴性表达,差异有统计学意义(P<0.05);Survivin胞浆阳性表达31例(50.8%),正常胃组织为阴性表达,差异有统计学意义(P<0.05)。结论 Survivin与COX-2可能有共同的激活机制,在胃癌的发生、发展过程中起重要作用。
Objective To investigate the role of cyclooxygenase-2 (COX-2) and survivin in the development and progression of gastric cancer. Methods Sixty-one gastric cancer tissues and 15 normal gastric tissues were selected. The expressions of COX-2 and Survivin in the two tissues were detected by immunohistochemistry. RESULTS: Of the 61 gastric cancer tissues, 46 were positive for COX-2 cytoplasm (75.4%), negative for normal gastric tissue (P <0.05), and 31 were cytoplasmic positive for Survivin (50.8 %), Normal gastric tissue was negative, the difference was statistically significant (P <0.05). Conclusion Survivin and COX-2 may have a common activation mechanism, which plays an important role in the occurrence and development of gastric cancer.