【摘 要】
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After central nervous system (CNS) injury, severed axons fail to regenerate and their disconnections to the original targets result in permanent functional deficits in patients (Mahar and Cavalli, 2018). Both the diminished intrinsic regenerative capacity
【机 构】
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Shriners Hospitals Pediatric Research Center,Department of Neural Sciences,Lewis Katz School of Medi
论文部分内容阅读
After central nervous system (CNS) injury, severed axons fail to regenerate and their disconnections to the original targets result in permanent functional deficits in patients (Mahar and Cavalli, 2018). Both the diminished intrinsic regenerative capacity of mature neurons and the inhibitory CNS milieu contribute to the regenerative failure following CNS injury. Glial cells have important physiological functions, including maintaining homeostasis, supporting and protecting neurons, regulating neuronal activities, and forming myelin (Gaudet and Fonken, 2018). In response to CNS injury, reactive glial cells shift their phenotype and activities and contribute to scar formation.
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