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小儿视神经通路胶质瘤系典型的低恶性胶质瘤,其病程难以预测,约1/3的视神经胶质瘤病人同时为神经纤维瘤病Ⅰ型(NF1),并伴有Moyamoya病症状。对视神经通路胶质瘤患者的放射治疗作用尚有争论。作者报道1971～1990年手术治疗的该种病例47例,其中5例放疗后发生Moyamoya征。47例中26例肿瘤侵犯视交叉,12例肿瘤集中在下丘脑,8例侵犯单侧视神经,1例侵犯双侧视神经。本文重点讨论视神经通路胶质瘤、NF1的放疗与Moyamoya征的关系。
Pediatric optic nerve pathway glioma is a typical low-grade glioma, the course of which is unpredictable. About one-third of patients with optic glioma are both neurofibromatosis type 1 (NF1) and Moyamoya disease. Radiation therapy in patients with optic nerve access glioma is still debated. The authors report 47 cases of surgical treatment of 1971-1990, of which 5 cases of Moyamoya signs of radiotherapy. Twenty-seven of the 47 patients had optic chiasm violations, 12 of them had tumors in the hypothalamus, 8 had unilateral optic nerves, and 1 had bilateral optic nerves. This article focuses on the optic nerve pathway glioma, NF1 radiotherapy and Moyamoya sign relationship.