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肺毛细血管通透性改变是许多工业或环境毒物所引起的急性肺水肿或慢性支气管炎的基本病理过程之一。在生理正常情况下,水及大部分盐溶液可自由透过毛细血管壁,血浆蛋白则几乎不能通过。当毒物或其代谢产物作用于毛细血管时,可能出现血管壁结构损害,增强了对血浆蛋白的通透性,促成肺水肿的发展。因此,可以用毛细血管通透性作为指标,以观察肺受损的情况。 以往,毒理学中多用美蓝染色法测定毛细血管通透性,用肺重量系数或X线摄片检查肺水肿程度,这些方法都不够敏感和精确。本文用标有放射性碘的人血清白蛋白,以透入受损肺组织之多少,来测定肺毛细血管通透性的变化。
Pulmonary capillary permeability change is one of the basic pathological processes of acute pulmonary edema or chronic bronchitis caused by many industrial or environmental toxicants. Under normal physiological conditions, water and most of the saline solution are free to penetrate the capillary wall, and plasma proteins hardly pass. When the poison or its metabolites acting on the capillaries, vascular wall damage may occur, enhance the permeability of plasma proteins, promote the development of pulmonary edema. Therefore, capillary permeability can be used as an indicator to observe lung damage. In the past, toxicology and more with methylene blue staining for capillary permeability, lung weight coefficient or radiographic examination of pulmonary edema, these methods are not sensitive enough and accurate. In this paper, radioactive iodine labeled human serum albumin, penetrate into the damaged lung tissue to determine the changes in pulmonary capillary permeability.