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传统的抗蛇毒血清是从全毒免疫的马或绵羊的血清中提取,但目前的免疫方法包括对马或绵羊进行的超免也不能达到对大多数临床上重要的毒素都产生免疫应答的目标。目前利物浦大学的Simon. C. Wagstaff等研究人员开发了一种最新的研制抗蛇毒血清的方法—通过鉴定蛇毒金属蛋白酶(SVMPs,SVMPs主要是产生持续性致死性出血,SVMPs很复杂,它具有多种功能型,能作用于多种底物)中有重要临床意义的7个部分,并将它们改造成单链DNA作为免疫原免疫小鼠产生特异抗体。为研发更合理的抗蛇毒血清制备方法提供了依据。
Traditional anti-snake venom serum is extracted from sera of fully immunized horses or sheep, but current immunization methods, including over-administration of horses or sheep, do not achieve the goal of producing an immune response to most clinically important toxins . At present, researchers at Simon C. Wagstaff at the University of Liverpool have developed a new method for the development of anti-snake venom serum-by identifying SVMPs, which are mainly persistent lethal hemorrhages, SVMPs are complex and have many Functional, can act on a variety of substrates) in the seven clinically important parts, and transform them into single-stranded DNA as immunogen to immunize mice to produce specific antibodies. It provided the basis for developing a more reasonable preparation method of anti-snake venom serum.