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[目的]探讨人参花提取物对酒精性脂肪肝的抑制作用.[方法]将SD大鼠随机分为正常对照组、模型对照组及人参花提取物组,正常对照组给予Lieber-DeCarli Control Diet饮食,模型对照组和人参花提取物组给予5%(体积分数)乙醇稀释的Lieber-DeCarli Control Diet建立酒精性脂肪肝大鼠模型,于第7周开始人参花提取物组每天灌胃给予人参花提取物300mg/kg,共10d.末次给药12h后取各组血液及肝组织,分别测定血清总胆固醇(TC)、三酰甘油(TG)、碱性磷酸酶(ALP)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、肿瘤坏死因子(TNF)-α及肝脏丙二醛(MDA)、谷胱甘肽(GSH)含量.[结果]与模型对照组比较,人参花提取物组血清TC,TG,ALP,ALT,AST,TNF-α及肝脏MDA含量均明显降低(P<0.05,P<0.01,P<0.001),而肝脏GSH水平明显升高(P<0.01).[结论]人参花提取物对酒精性脂肪肝的发生具有抑制作用.
[Objective] To explore the inhibitory effect of extract of ginseng flower on alcoholic fatty liver. [Methods] SD rats were randomly divided into normal control group, model control group and ginseng flower extract group, and normal control group were given Lieber-DeCarli Control Diet Diet, model control group and ginseng flower extract group were given 5% (volume fraction) ethanol dilution Lieber-DeCarli Control Diet to establish alcoholic fatty liver rat model, the seventh week began ginseng flower extract group gavage given daily ginseng After the last administration, the blood and liver tissues of each group were taken and the levels of total cholesterol (TC), triglyceride (TG), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor (TNF) -α and hepatic malondialdehyde (MDA) and glutathione (GSH) contents were measured. [Results] Compared with the model control group, Serum levels of TC, TG, ALP, ALT, AST, TNF-α and liver MDA were significantly decreased (P <0.05, P <0.01, P <0.001) ] Ginseng flower extract on alcoholic fatty liver has an inhibitory effect.