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应用放射免疫法对妊娠早、中、晚期的胎盘组织及血清中ＳＰ１、ｈｐＬ和ｈｃＧ水平进行了测定，并对孕晚期异常妊娠进行了观察。结果表明：胎盘组织和母血清的ｈｃＧ水平随孕周增加而逐渐降低。而ＳＰ１和ｈｐＬ含量则随孕周的增加而逐渐增加。妊高征和ＩＶＧＲ孕妇血清ＳＰ１值明显低于正常妊娠组（Ｐ＜０．０１），我们认为测定孕妇血ＳＰ１、ｈｐＬ和ｈｃＧ值均可反映胎盘整体的功能状态
The levels of SP1, hpL and hcG in placenta tissue and serum of early, middle and late pregnancy were measured by radioimmunoassay, and abnormal pregnancy in third trimester of pregnancy was observed. The results showed that placental tissue and maternal serum hcG levels gradually decreased with gestational weeks. While SP1 and hpL content increased with the increase of gestational age. The serum SP1 value of PIH and IVGR pregnant women was significantly lower than that of normal pregnancy (P <0.01). We think the determination of serum SP1, hpL and hcG values in pregnant women can reflect the functional status of the whole placenta