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目的:探讨胃癌中VEGF,Fltl,bFGF,P53的表达及意义方法:应用SABC免疫组化法,研究VEGF,Fltl,bFGF, P53在胃癌中表达及与胃癌生长转移、临床病理特征、预后的关系. 结果:胃癌VEGF表达与肿瘤浸润深度有关(浆膜、浆膜外vs 肌层和黏膜层,P<0.01).P53表达与淋巴结转移相关(P53 阳性淋巴结转移组vs P53阴性淋巴结无转移组,P<0.05). VEGF与Fltl表达呈正相关(VEGF表达在Fltl阳性组vs在Fltl阴性组,P<0.01);影响胃癌预后的因素有临床病理分期、VEGF表达、肿瘤浸润深度、手术方式.Kaplan-Meier 研究显示VEGF表达与胃癌生存预后相关(P<0.05).Fltl, bFGF,P53表达与生存预后无关(P>0.05). 结论:P53表达与淋巴结转移相关.VEGF表达与肿瘤浸润深度和胃癌生存预后相关,VEGF表达可作为预测胃癌预后一项很好的指标.
Objective: To investigate the expression and significance of VEGF, Fltl, bFGF and P53 in gastric cancer.Methods: The expression of VEGF, Fltl, bFGF and P53 in gastric carcinoma was studied by SABC immunohistochemistry and their correlations with the growth, metastasis, clinicopathological characteristics and prognosis of gastric carcinoma .Results: The expression of VEGF in gastric cancer was related to the depth of tumor invasion (serosa, extravasar, muscle and mucosa, P <0.01) .The expression of p53 was correlated with lymph node metastasis (P53 positive lymph node metastasis vs P53 negative lymph node without metastasis, P <0.05) .VEGF and Fltl expression was positively correlated (VEGF expression in Fltl positive group vs Fltl negative group, P <0.01); factors that influence the prognosis of gastric cancer include clinicopathological stage, VEGF expression, depth of tumor invasion, operation mode.Kaplan -Meier study showed that the expression of VEGF correlated with the prognosis of gastric cancer (P <0.05) .Fltl, bFGF, P53 expression had no correlation with survival prognosis (P> 0.05) .Conclusion: The expression of P53 is correlated with lymph node metastasis, Survival and prognosis, VEGF expression can be used as a good indicator of prognosis of gastric cancer.