设计合成了4种新型卟啉-5-氟尿嘧啶化合物,收率27.1%~58.3%,mp>300℃。确定了合成反应的最佳条件,研究了目标化合物的分离方法。通过红外光谱、紫外光谱、核磁共振谱和质谱测试技术对化合物结构和组成进行了确认。经抗癌活性实验表明,化合物D1、C2、D2对小鼠S180肉瘤生长有明显的抑制作用。 Four novel porphyrin-5-fluorouracil compounds were designed and synthesized with yields of 27.1% -58.3% and mp> 300 ℃. The optimal conditions for the synthesis were determined, and the separation methods of the target compounds were studied. The structure and composition of the compounds were confirmed by IR, UV, NMR and MS. The anti-cancer activity experiments show that compounds D1, C2, D2 on S180 sarcoma tumor growth was significantly inhibited.