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二尖辨脱垂(MVP)是一种常见疾病,其流行病学为5～10％。早先认为它是一种良性综合征,现已观察到该病可伴有严重并发症,如二尖辨关闭不全、感染性心内膜炎、心律失常、卒中或一过性脑缺血发作等。因为血小板的激活在血栓的发生中可能起关键性作用,本文作者通过测定33例经越声心动图证实的MVP病人血浆中的血小板因子(PF_4)水平,以估计血小板激活情况。检查结果明表,33例MVP病人中有12例PF_4增高(占36％),而对照组55例中仅5例PF_4增高。
Mitral prolapse (MVP) is a common disease with an epidemiology of 5 to 10%. Earlier it was considered a benign syndrome and it has now been observed that the disease can be accompanied by serious complications such as binaural incompetence, infective endocarditis, arrhythmia, stroke or transient ischemic attack . Because platelet activation may play a key role in the development of thrombi, the authors estimated platelet activation (PF_4) in plasma from 33 patients with MVP confirmed by echocardiography. Results of the examination showed that in the 33 cases of MVP patients, 12 cases of PF4 increased (36%), while in the control group, only 5 cases of PF4 increased.