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目的:探讨急性白血病(AL)、病理产科及肝硬化合并出血患者出凝血指标改变的有关特点,为临床治疗提供依据。方法:收集各类患者治疗前静脉抗凝血,检测血小板、凝血酶原时间(PT)、部分凝血活酶时间(APTT)以及纤维蛋白原(FIB)含量,与正常对照组进行比较,各组患者之间也进行了比较。结果:与正常对照组比较,AL及肝硬化组四项指标均差异有非常显著性(P<0.01);病理产科组PT和APTT差异有非常显著性(P<0.01)。与AL组比较,病理产科组BPC、肝硬化组APTT差异有非常显著性(P<0.01)。病理产科组与肝硬化组比较BPC、APTT差异有非常显著性(P<0.01)。结论:PT、APTT是合并出血患者最为有效的筛选指标,肝硬化组的APTT延长更为明显,观察这些患者的出凝血指标,对于指导临床用药,预防并发症的发生有重要意义。
Objective: To investigate the characteristics of coagulation changes in patients with acute leukemia (AL), pathology, obstetrics and cirrhosis complicated with hemorrhage and provide the basis for clinical treatment. Methods: The anticoagulant blood, platelet, prothrombin time (PT), partial thromboplastin time (APTT) and fibrinogen (FIB) were measured in all patients before treatment, compared with the normal control group, Patients were also compared. Results: Compared with the normal control group, there were significant differences in the four indexes of AL and cirrhosis (P <0.01). The difference of PT and APTT in pathology and obstetrics group was significant (P <0.01). Compared with AL group, pathological obstetric group BPC, cirrhosis group APTT difference was significant (P <0.01). Pathological obstetric group and cirrhosis group compared BPC, APTT difference was significant (P <0.01). Conclusions: PT and APTT are the most effective screening indexes for patients with hemorrhage. The prolongation of APTT is more obvious in cirrhotic patients. To observe the coagulation index in these patients is of great significance for guiding clinical medication and preventing the occurrence of complications.