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目的:探讨股前外侧嵌合穿支皮瓣对糖尿病足溃疡（DFU）创面修复的临床疗效。方法:2018年1月至2019年12月,共收治14例II型糖尿病足部溃疡,男10例,女4例,年龄49~58岁。其中单纯周围神经病变10例,周围神经病变合并血管病变4例,无单独血管病变患者。在严格控制患者血糖的基础上,对Wagner 2级以上DFU进行清创后抗生素骨水泥覆盖或填充,2~3周后采用股前外侧嵌合穿支皮瓣移植修复,皮瓣大小8 cm×3 cm~27 cm×7 cm。术后定期随访。结果:术后13块皮瓣一期成活,1块发生静脉危象,积极探查后皮瓣完全成活。随访6~12个月,供区和受区愈合良好,皮瓣外形好,质地佳,功能恢复满意。结论:股前外侧嵌合穿支皮瓣可修复DFU创面,临床效果良好,能有效改善患者生存质量。“,”Objective:To investigate the clinical effect of the anterolateral thigh perforator chimeric flap in the treatment of the wound of diabetic foot ulcer (DFU) .Methods:From January, 2018 to December, 2019, 14 cases wound of DFU of type II diabetic were treated by anterolateral thigh chimeric perforator flap. The patients were 10 males and 4 females, at 49 to 58 years old. Of the 14 patients, 10 with simple peripheral neuropathy, 4 with peripheral neuropathy complicated with vascular disease, and none with single vascular disease. With strict control of patients' blood glucose, antibiotics blended bone cement was applied or filled onto grade 2 or higher grade Wagner's DFU after debridement. In addition, the anterolateral thigh chimeric perforator flap was transferred 2 to 3 weeks later. The size of flap was 8 cm×3 cm-27 cm×7 cm. Regular followed-up were made after surgery.Results:Thirteen flaps survived in one stage after surgery. The other 1 flap had venous vascular crisis, and survived completely after active exploration. The patients were followed-up for 6-12 months. All the flaps survived well in good shape and texture. The donor and recipient areas healed well. The functional recoveries of the DF were satisfactory.Conclusion:Application of anterolateral thigh perforator chimeric flap in repair of the refractory wound of DF achieves a good clinical outcome and effectively improves the life quality of patients.