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目的探讨妊娠期乳腺假血管瘤样间质增生(PASH)的临床病理特征、诊断、治疗与预后。方法复习1例妊娠期乳腺假血管瘤样间质增生的临床病理资料并文献复习。结果患者女性,17岁。妊娠时肿物迅速增大,流产后肿物明显缩小,短期内再次妊娠时,肿物持续增大。粗针穿刺活检结果提示良性间叶源性肿瘤。妊娠4个月时,患者接受肿物切除术。术后病理示乳腺间质内出现特征性的裂隙样中空间隙,形似不规则的血管腔,内衬无明显异型的不连续的梭形细胞。随访36个月,无复发。结论妊娠期以快速增大的包块为特征的乳腺假血管瘤样间质增生非常罕见,确诊依赖于组织病理学检查及免疫组化结果,治疗以手术切除为主,预后好。
Objective To investigate the clinicopathological characteristics, diagnosis, treatment and prognosis of pregnancy-induced pseudarthomampanic interstitium (PASH). Methods One case of mammary pseudo-hemangiomas interstitial hyperplasia during pregnancy was reviewed. Results Female patient, 17 years old. Rapid enlargement of pregnancy, abortion after the tumor was significantly reduced, short-term pregnancy again, the tumor continued to increase. Coarse needle biopsy results suggest benign mesenchymal tumors. At 4 months of gestation, the patient undergoes a tumor resection. Postoperative pathological breast interstitial showed characteristic slit-like hollow space, irregular shape of the vascular lumen, lined with no significant abnormal discontinuous spindle cells. Follow-up 36 months, no recurrence. Conclusions The hyperplasia of mammary pseudo-angiomatous tumor characterized by rapid enlargement during pregnancy is very rare. The diagnosis depends on histopathological examination and immunohistochemical results. The treatment is mainly surgical resection and the prognosis is good.