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目的探讨β-地中海贫血实验室诊断的临床意义。方法曲靖市第二人民医院2008-03-2009-12用日本东亚希森美康XT2000i血细胞仪进行血液细胞分析,对检测结果红细胞指数异常者,Hb<110g/L、MCV<70fl、RDW-CV<16.5的14例幼儿进行了血红蛋白电泳、抗碱血红蛋白实验、不稳定血红蛋白测定。结果通过实验室诊断14例患儿中检出5例β-地中海性贫血幼儿。结论当血常规显示明显小细胞低色素性贫血时,RDW-CV正常或稍偏高患者必须做HB电泳分析,以鉴别血红蛋白疾病还是缺铁性贫血,对于暂时无条件开展基因检测的情况下,对小细胞低色素性贫血鉴别诊断有积极的临床意义。
Objective To investigate the clinical significance of β-thalassemia laboratory diagnosis. Methods Qujing Second People ’s Hospital 2008-03-2009-12 Blood cells were analyzed by X-ray fluorescence spectrometry (XT2000i) from East Asia, Japan. The detection index of abnormal erythrocyte index (Hb <110g / L, MCV <70fl, RDW-CV 14 cases of children <16.5 hemoglobin electrophoresis, anti-alkali hemoglobin test, unstable hemoglobin determination. Results Among the 14 cases diagnosed in the laboratory, 5 cases of β-thalassemia were detected in children. Conclusions When blood tests show marked microcytic hypochromic anemia, patients with normal or slightly elevated RDW-CV must be analyzed by HB electrophoresis to identify hemoglobin disease or iron-deficiency anemia. For the case of a gene test that is unconditionally and unconditionally performed, The differential diagnosis of small cell hypochromic anemia has a positive clinical significance.