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研究诺迪康对大鼠实验性心肌缺血的影响。结扎Wistar大鼠左冠状动脉造成急性心肌缺血 ,在结扎冠脉 15min后经十二指肠给药 ,记录给药前及给药后不同时间胸前多导联心电图 (9点 ) ,以 ST和NST来反映心肌缺血程度和范围 ;于结扎冠脉后 180min ,摘取心脏 ,用N -BT染色确定心肌梗塞面积。与空白对照相比 ,诺迪康 1 0 0g/kg、0 5 0g/kg在 30min时使 ST分别下降 2 9 92 %、2 6 81% (P <0 0 1) ;使NST分别降低 14 47%、8 82 % (P <0 0 1)持续 180min ,使梗塞面积由对照组的 15 14%分别降到 8 15 %、13 38% (P <0 0 1,P <0 0 5 )。诺迪康可降低大鼠实验性心肌缺血程度和缺血范围 ,减少梗塞面积。
To study the effect of Nuodikang on experimental myocardial ischemia in rats. Ligation of Wistar rats left coronary artery caused by acute myocardial ischemia, 15min after ligation of the coronary artery via the duodenum, before and after administration record multi-lead ECG chest (9 points) to ST And NST to reflect the extent and extent of myocardial ischemia; 180min after ligation of the coronary artery, the heart was removed and infarcted area was confirmed by N-BT staining. Compared with the blank control, the NOD1O0g / kg and 050g / kg decreased ST by 292% and 26% (P <0.01) respectively at 30min, and reduced the NST by 1447 %, 82 82% (P <0.01) for 180 minutes, respectively. The infarct size was reduced from 15 14% in the control group to 81.5% and 13 38% in the control group (P <0.01, P <0.05). Nuodikang can reduce the extent of experimental myocardial ischemia and ischemia in rats, reduce infarct size.