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目的阐明群体性预防接种反应与季节性呼吸道传染病的判别,为处理群发性事件提供借鉴。方法开展流行病学调查,进行临床诊断与血清学(病原学)分离鉴定,病原学采用MDCK法进行病毒分离。结果流行病学调查显示接种甲型肝炎疫苗与否和发病率无相关关系;患者临床症状、体征类似上呼吸道感染;从24例患者中分离到A型流感病毒8株,分离阳性率为33.3%。结论该宗群体性发热是流行性感冒的局部小流行,而非接种甲型肝炎疫苗反应。从而排除了一起接种甲型肝炎疫苗偶合群体性热病引起的纠纷,为今后鉴别预防接种后不良事件提供参考,消除该事件对计划免疫/扩大免疫接种的负面影响。
Objective To elucidate the discrimination between group vaccination and seasonal respiratory infectious diseases and provide reference for the treatment of mass incidents. Methods To carry out epidemiological investigation, clinical diagnosis and serological (etiological) isolation and identification, etiology using MDCK method for virus isolation. Results Epidemiological survey showed that there was no correlation between the incidence of hepatitis A vaccine and the incidence of hepatitis A. The clinical symptoms and signs were similar to those of upper respiratory tract infection. Eight influenza A viruses were isolated from 24 patients and the positive rate was 33.3% . Conclusions This group of colds is a local pandemic rather than a non-vaccinated hepatitis A vaccine. Thus eliminating the disputes caused by the combination of Hepatitis A vaccine with herpes simplex fever and providing references for the identification of adverse events after vaccination in the future and eliminating the negative impact of the incident on planned immunization / expansion immunization.