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骨肉瘤是骨科常见恶性肿瘤，其发生和发展涉及到多基回，多分子水平的变化。迄今为止，p16基因蛋白及增殖细胞核抗原（PCNA）在骨肉瘤中的表达规律与患者预后关系的研究尚未见报道。我们采用改良的免疫组化ABC法，检测了32例骨肉瘤中p16基因蛋白及PCNA的表达情况，以探讨其临床
Osteosarcoma is a common malignancy in orthopedics. The occurrence and development of osteosarcoma involves multi-basal gyral and multi-molecular level changes. So far, studies on the relationship between the expression pattern of p16 gene protein and proliferating cell nuclear antigen (PCNA) in osteosarcoma and the prognosis of patients have not been reported. We used a modified immunohistochemical ABC method to detect the expression of p16 gene protein and PCNA in 32 cases of osteosarcoma to explore its clinical