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常规的血清钙筛检证明,与甲状旁腺机能亢进(HPT)有关的甲状旁腺瘤是非常多的,但其发病机理仍然是一个谜.尽管大多数HPT病例的原因是不清楚的,但是与慢性肾衰竭有关的环境因子和吸收不良是某些病例的明显因素.肿瘤发生过程中的突变也影响到与射线有关的那些HPT病例、遗传性HPT的病例以及多发性内分泌瘤综合征.1971年,Knudson提出了肿瘤始动的二次突变事件或二次击中学说(two-hit theory),并且认为比较遗传性和散发性视网膜母细胞瘤的发病年龄符合这种模型.在
Conventional serum calcium screening proves that parathyroid adenomas associated with hyperparathyroidism (HPT) are numerous, but its pathogenesis remains a mystery. Although the cause of most HPT cases is unclear, Environmental factors associated with chronic renal failure and malabsorption are conclusive factors in some cases. Mutations during tumorigenesis also affect those ray-related HPT cases, cases of hereditary HPT, and multiple endocrine neoplasia syndromes. In 2000, Knudson proposed a second mutation event or two-hit theory of tumor initiation, and considered that comparing the onset age of hereditary and sporadic retinoblastoma with this model.