论文部分内容阅读
目的 评价去甲长春花碱 (vinorelbine ,NVB)联合顺铂 (cisplatin ,DDP)治疗非小细胞肺癌的近期疗效、毒副反应、中位生存期及生存率。方法 对 2 2 0例不能手术的非小细胞肺癌患者采用NVB联合DDP化疗 ,NVB 2 5～ 3 0mg/(m2 ·d) ,第 1、5 (或第 8)天 ;DDP 60～ 80mg/(m2 ·d) ,第 2天 ,2 8天为一周期。完成两周期以上评价疗效 ,观察毒副反应并进行随访。结果 全组有效率 (RR)为 3 0 .9% ( 68/2 2 0 ) ,初治者有效率为 3 1.3 % ( 5 1/163 ) ,复治者为 2 9.8% ( 17/5 7)。全组中位生存期 8.3月 ,1年生存率 3 9.2 3 % ,2年生存率 19.3 1% ,3年生存率 6.3 2 %。主要毒性反应为骨髓抑制和消化道反应。结论 NVB联合DDP是治疗非小细胞肺癌有效且耐受性好的方案 ,骨髓抑制为其剂量限制性毒性。
Objective To evaluate the short-term curative effect, toxicity, median survival and survival rate of vinorelbine (NVB) combined with cisplatin (DDP) in the treatment of non-small cell lung cancer. Methods Twenty 220 patients with unresectable non-small cell lung cancer were treated with NVB combined with DDP chemotherapy, NVB 2.5 ~ 3.0 mg / (m 2 · d), day 1, 5 (or 8), and DDP 60-80 mg / m2 · d), the first two days, 28 days for a period. To complete the evaluation of more than two cycles of efficacy, observe the side effects and follow-up. Results The total effective rate (RR) was 30.9% (68/2 20), the effective rate of the first treatment was 3 1.3% (5 1/163) and the second was 8.8% (17/5 7 ). The median survival time 8.3 months, 1 year survival rate of 3 9.23%, 2-year survival rate of 19.3 1%, 3-year survival rate of 6.3 2%. The main toxicities are myelosuppression and digestive tract reactions. Conclusion NVB combined with DDP is an effective and well-tolerated regimen for the treatment of non-small cell lung cancer with bone marrow suppression as its dose-limiting toxicity.