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目的研究国产甲基叔丁基醚(MTBE)的亚慢性毒性,为职业及环境污染危害寻找有用的健康监护指标.方法采用大鼠静式吸入染毒法,4H/D,染毒两个月.试验设0,400,3000和8000PPM四个剂量组,每组8只SD大鼠,雌雄各半.结果尽管8000PPM组动物平均体重略低,但与对照组比较,差异无显著意义(P＞0?05).各染毒组动物的心、肺、肝、脾、肾脏外观及平均湿重也均未见明显影响.但8000PPM组的红细胞总数及血红蛋白较对照明显降低,且有剂量?反应关系.在所测定的18项血生化指标中,仅见8000PPM组动物的胆红素及甘油三酯明显升高.由病理结果可见,肾脏病理改变与国外报告基本一致.另见高剂量组动物中,肺及肝也有一定的病理改变.结论8000PPM染毒两个月,对大鼠的体重、脏器湿重无明显影响.但对血常规及某些血生化指标均有一定影响,对肺、肝、肾也有一定损伤作用.“,”Objective To study the sub chronic toxicity of methyl tertiary butyl ether(MTBE)prepared in China and to look for a useful indicators for health surveillance.Methods MTBE was inhaled in a static status by rats four hours a day for two months,which were divided into four groups based on their exposed dose(0,400,3 000,and 8 000 ppm,respectively),each with eight rats and half for male and female.Results Average body weight was a little bit l...