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目的:通过动物实验验证和血通脉颗粒与功能主治有关的主要药效学作用,为临床用药的有效性提供药理学依据。方法:(1)小鼠腹腔注射0.6%的冰醋酸,以10 min内小鼠扭体次数为指标(小鼠扭体法),观察药物的镇痛作用;(2)将小鼠放入装有10 g钠石灰,容积为250 mL不漏气的广口瓶内,以小鼠呼吸停止时间为指标,观察药物对小鼠耐常压缺氧作用;(3)利用肾上腺素造成小鼠肠系膜微循环障碍,观察药物对小鼠肠系膜微循环的影响。结果:(1)显著减少0.6%冰醋酸引起的小鼠扭体次数;(2)显著延长小鼠常压缺氧条件下的存活时间;(3)明显改善小鼠肠系膜微循环障碍。结论:和血通脉颗粒小鼠低剂量组3.9 g(生药)/kg、中剂量组7.8g(生药)/kg、高剂量组15.6 g(生药)/kg具有镇痛作用;具有增强小鼠耐常压缺氧能力的功效;具有改善微循环的作用。
OBJECTIVE: To validate the main pharmacodynamic effects of XQMT on the function and main function of blood circulation by animal experiments, and to provide a pharmacological basis for the effectiveness of clinical medication. Methods: (1) The mice were intraperitoneally injected with glacial acetic acid 0.6%, and the number of writhing times in mice was used as an index (mouse writhing method) to observe the analgesic effect of the drugs. (2) There is 10 g sodium lime, a volume of 250 mL airtight jar, the mouse breath stop time as an indicator to observe the effect of drugs on mice with anoxia and anoxia; (3) the use of epinephrine in mice caused by mesentery Microcirculation, observe the effects of drugs on the mesenteric microcirculation in mice. Results: (1) The number of writhing in mice caused by glacial acetic acid was significantly reduced by 0.6%; (2) The survival time under hypobaric hypoxia was significantly prolonged; (3) The mesenteric microcirculation disturbance was significantly improved. Conclusion: Compared with low-dose Xuemai Granule mice, the dosage of 3.9g (crude drug) / kg, middle dose group 7.8g (crude drug) / kg and high dose group 15.6g (crude drug) / kg have analgesic effect; Anti-atmospheric pressure hypoxia ability; with the role of microcirculation.