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重症急性胰腺炎(SAP)是临床常见的危重疾病,越来越多的证据表明,SAP是胰腺自身消化启动的严重全身炎症反应性疾病,炎症细胞被过度激活并大量释放细胞因子,由此产生的细胞因子级联反应是SAP病情加重的重要原因。连续性血液净化(CBP)作为一种重要的辅助治疗措施,可削弱炎症介质峰值,稳定内环境,从而治疗SAP导致的多脏器功能损害,在缓解症状、降低并发症的发生率、缩短并发症的持续时间、降低病死率方面起着重要的作用,在改善患者预后方面效果良好。本文结合SAP的发病特点,对CBP治疗SAP的机制、目前临床研究及进展作一综述。
Severe Acute Pancreatitis (SAP) is a clinically common and critically ill condition. There is increasing evidence that SAP is a severe systemic inflammatory response disorder initiated by the pancreatic autogasia. Inflammatory cells are over-activated and release cytokines in large quantities, resulting in The cytokine cascade is an important reason for the aggravation of SAP. Continuous blood purification (CBP) as an important adjuvant therapy can reduce the peak of inflammatory mediators and stabilize the internal environment, thus treating multiple organ damage caused by SAP, relieving symptoms, reducing the incidence of complications and shortening the concurrent The duration of the disease, reduce the mortality plays an important role in improving the prognosis of patients with good results. In this paper, the pathogenesis of SAP, CBP treatment of SAP mechanism, the current clinical research and progress are reviewed.