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醛缩酶(ALD)属于一种糖酵解酶,其同工酶可分为肌肉、肝及脑三型,以往由于检测方法繁琐且不敏感,临床应用受到限制.作者创用放射免疫双抗体法直接测定肌肉型醛缩酶(M-ALD)活性.对91例各种肝病患者和41名健康人的检测结果表明,该试验对于鉴别良性及恶性肝病很有价值.M-ALD活性的测定结果是:41名正常人平均为171±39ng/ml(130～210ng/ml);11例急性肝炎〔除1例肝功严重损害者为220ng/ml外〕均在正常范围,且M-ALD活性与GOT、GPT活性无关;3例暴发型肝炎(均死亡)M-ALD显著增高(1060～1200ng/ml);20例慢性肝炎(活动型16例,非活动型4例)、16例肝硬化(代偿期3例,失代偿期13例)、5例胆石症及3例肝囊肿患者均在正常范围;
Aldolase (ALD) is a glycolytic enzyme, the isozyme can be divided into three types of muscle, liver and brain, the past due to tedious and insensitive detection methods, clinical application is limited. The author of radioimmunoassay Direct determination of muscle aldolase (M-ALD) activity in 91 cases of various liver disease patients and 41 healthy people test results show that the test for the identification of benign and malignant liver disease is valuable.M-ALD activity determination The results were: 41 normal average 171 ± 39ng / ml (130 ~ 210ng / ml); 11 cases of acute hepatitis [except one case of severe liver damage was 220ng / ml] were in the normal range, and M-ALD Activity was not related to GOT and GPT activity. M-ALD was significantly higher in all three cases (1060-1200ng / ml), 20 cases of chronic hepatitis (16 cases of active type and 4 cases of inactive type), 16 cases of liver Sclerosis (3 cases of decompensation, decompensation in 13 cases), 5 cases of cholelithiasis and 3 cases of liver cysts were in the normal range of patients;