已证实对血吸虫虫卵抗原的细胞免疫反应在肝脾型血吸虫病病理损伤中具有重要作用。以慢性日本血吸虫病患者建立的日本血吸虫可溶性虫卵抗原(SEA)的T细胞克隆均能对SEA低分子量部分(7～18kD)起反应,而对高分子量部分则否。为此,试图对这种反应差别进行分析,并确定慢性日本血吸虫病人的T细胞反应是否存在表位特异性 It has been demonstrated that the cellular immune response to Schistosoma japonicum egg antigen plays an important role in the pathological damage of hepatosplenic schistosomiasis. T-cell clones of Schistosoma japonicum soluble egg antigen (SEA) established in patients with chronic Japanese schistosomiasis could both respond to the low molecular weight fraction of SEA (7-18 kD) and to the high molecular weight fraction. To this end, attempts to analyze this difference in response and to determine whether there is an epitope-specific T cell response in chronic Schistosoma japonicum