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目的:研究右美托咪定分别与3种阿片类药物(舒芬太尼、芬太尼和布托啡诺)联合用药时的稳定性,以供临床合理用药参考。方法:右美托咪定分别与阿片类药物舒芬太尼、芬太尼及布托啡诺配伍,配制在0.9%氯化钠注射液中,室温放置,在0,24,48和96 h分别取样,进行性状、pH、不溶性微粒检查,并进行质谱检测。结果:在96 h内,配伍溶液均澄清透明,pH稳定,不溶性微粒检查符合规定,质谱检测显示无新物质生成。结论:3种配伍用药方案安全、合理、具有临床可行性。
OBJECTIVE: To study the stability of dexmedetomidine combined with three opioids (sufentanil, fentanyl and butorphanol) for reference of clinical rational drug use. Methods: Dexmedetomidine and opiate drugs sufentanil, fentanyl and butorphanol compatibility, formulated in 0.9% sodium chloride injection, at room temperature, at 0,24,48 and 96 h Separate sampling, traits, pH, insoluble particulate examination, and mass spectrometry. Results: The compatibility solution was clear and transparent within 96 h, the pH was stable, the insoluble particles were checked, and no new substances were detected by mass spectrometry. Conclusion: The three kinds of compatibility drug regimen are safe, reasonable and clinically feasible.