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为了解目前新生儿呼吸道感染的主要病原菌及耐药情况 ,回顾分析1996年1月～2000年12月342例新生儿气管插管下取痰作细菌培养和药敏试验结果。资料显示 ,1996年～2000年共检出病原菌418株 ,革兰阴性杆菌占88.8% ,其中肺炎克雷伯菌、铜绿假单胞菌、不动杆菌为主要病原菌。3种细菌对氨苄青霉素、庆大霉素、复方新诺明、第一代和第二代头孢菌素耐药率高 ,肺炎克雷伯菌对泰能和环丙沙星较敏感 ,耐药率为1.6%和2.9% ;铜绿假单胞菌对泰能、环丙沙星、丁胺卡那霉素和氧哌嗪青霉素较敏感 ,耐药率分别为4.9 %、9.5 %、28.6 %和25.6 % ;对不动杆菌较为敏感的药物是环丙沙星和泰能 ,耐药率为23.7 %和27.8 %。肺炎克雷伯菌和铜绿假单胞菌一直是我院新生儿呼吸道感染的重要病原菌 ,但2000年铜绿假单胞菌的分离率明显降低 ;从1998年开始不动杆菌成为感染的主要病原菌 ;2000年脑膜败血黄杆菌也成为感染的主要病原菌。提示革兰阴性杆菌是新生儿呼吸道感染的重要病原菌 ,且耐药率高 ,应积极防治
To understand the current pathogens and drug resistance of neonatal respiratory infections, retrospective analysis from January 1996 to December 2000 342 cases of neonatal sputum aspirate for bacterial culture and drug sensitivity test results. Data show that from 1996 to 2000, a total of 418 pathogenic bacteria were detected, Gram-negative bacilli accounted for 88.8%, of which Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter as the main pathogen. Three strains of ampicillin, gentamicin, cotrimoxazole, first-generation and second-generation cephalosporins resistant rate of Klebsiella pneumoniae and ciprofloxacin more sensitive to resistant The rates of Pseudomonas aeruginosa were more sensitive to tenecin, ciprofloxacin, amikacin and piperacil penicillin, and the rates of resistance were 4.9%, 9.5%, 28.6% and 25.6% respectively. The drug sensitive to Acinetobacter spp was ciprofloxacin and tacrine, with drug resistance rates of 23.7% and 27.8%. Klebsiella pneumoniae and Pseudomonas aeruginosa has been an important pathogen of neonatal respiratory infection in our hospital, but the isolation rate of Pseudomonas aeruginosa was significantly reduced in 2000; Acinetobacter became the main pathogen of infection since 1998; Flavobacterium meningitidis also became the main pathogen of infection in 2000. Tip Gram-negative bacilli is an important neonatal respiratory tract infection pathogens, and the high rate of resistance should be actively controlled